Personalising docetaxel and G-CSF schedules in cancer patients by a clinically validated computational model

@inproceedings{Vainas2012PersonalisingDA,
  title={Personalising docetaxel and G-CSF schedules in cancer patients by a clinically validated computational model},
  author={Oded Vainas and Samuel Ariad and Omalhassan Amir and Wilmosh Mermershtain and Vladimir Vainstein and M. Kleiman and Omri Inbar and Radel Ben-Av and Abhik Mukherjee and Stephen Y. T. Chan and Zvia Agur},
  booktitle={British Journal of Cancer},
  year={2012}
}
Background:This study was aimed to develop a new method for personalising chemotherapeutic and granulocyte colony-stimulating factor (G-CSF) combined schedules, and use it for suggesting efficacious chemotherapy with reduced neutropenia.Methods:Clinical data from 38 docetaxel (Doc)-treated metastatic breast cancer patients were employed for validating a new pharmacokinetic/pharmacodynamics model for Doc, combined with a mathematical model for granulopoiesis. An optimisation procedure was… CONTINUE READING