• Corpus ID: 26193978

Personal and Historical Perspectives History of the Design of Captopril and Related Inhibitors of Angiotensin Converting Enzyme

@inproceedings{Cushman2005PersonalAH,
  title={Personal and Historical Perspectives History of the Design of Captopril and Related Inhibitors of Angiotensin Converting Enzyme},
  author={David W. Cushman and Miguel A. Ondetti},
  year={2005}
}
In describing the development of captopril and related antihypertensive drugs, we hope to resurrect a more specific meaning for the term "drug design," namely, the logical process whereby molecules are constructed for precise fit with a macromolecular receptor. Thus defined, drug design requires direct or indirect knowledge of the nature of the receptor, which in this case is the active center of a peptidase known historically as angiotensin converting enzyme (ACE). We believe that the… 

Beyond Carbon: The Contributions of South American Tropical Humid and Subhumid Forests to Ecosystem Services

Tropical forests are recognized for their role in providing diverse ecosystem services (ESs), with carbon uptake the best recognized. The capacity of tropical forests to provide ESs is strongly

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