Persisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shock

@article{Monneret2006PersistingLM,
  title={Persisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shock},
  author={Guillaume Monneret and Alain Lepape and N. Voirin and Julien Boh{\'e} and Fabienne Venet and A Debard and H{\'e}l{\`e}ne Thizy and Jacques Bienvenu and François Gueyffier and Philippe Vanhems},
  journal={Intensive Care Medicine},
  year={2006},
  volume={32},
  pages={1175-1183}
}
The immediate overwhelming release of inflammatory mediators in septic shock is rapidly followed by strong anti-inflammatory responses inducing a state of immunosuppression. The patients who survive the initial hyper-inflammatory step of septic shock but subsequently die may be those who do not recover from immunosuppression. We assessed whether a low monocyte human leukocyte antigen-DR (mHLA-DR) expression, proposed as a marker of immunosuppression, is an independent predictor of mortality in… CONTINUE READING

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