Persisting behavioral consequences of prenatal domoic acid exposure in rats.

  title={Persisting behavioral consequences of prenatal domoic acid exposure in rats.},
  author={Edward D. Levin and Kristen Pizarro and Wyki Gina Pang and Jerry Harrison and John S. Ramsdell},
  journal={Neurotoxicology and teratology},
  volume={27 5},
To investigate the behavioral effects of prenatal exposure to the marine toxin domoic acid, pregnant female rats were injected subcutaneously with 0, 0.3, 0.6, or 1.2 mg/kg of domoic acid on gestational day 13. The offspring were then run through a behavioral testing battery to determine the developmental effects of the toxin on spontaneous alternation in the T-maze, on locomotor activity in the Figure-8 maze, and on working memory in the 8-arm radial maze. In the T-maze, no significant domoic… CONTINUE READING
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