Persisting Mixed Cryoglobulinemia in Chikungunya Infection

  title={Persisting Mixed Cryoglobulinemia in Chikungunya Infection},
  author={Manuela Oliver and Marc Grandadam and Catherine Marimoutou and Christophe Rogier and {\'E}lisabeth Botelho-Nevers and Hugues J. Tolou and Jean-Luc Moalic and Philippe Kraemer and Marc Morillon and J J Morand and Pierre Yves Jeandel and Philippe Parola and Fabrice Simon},
  journal={PLoS Neglected Tropical Diseases},
  pages={123 - 137}
BACKGROUND Chikungunya virus (CHIKV), an arbovirus, is responsible for a two-stage disabling disease, consisting of an acute febrile polyarthritis for the first 10 days, frequently followed by chronic rheumatisms, sometimes lasting for years. Up to now, the pathophysiology of the chronic stage has been elusive. Considering the existence of occasional peripheral vascular disorders and some unexpected seronegativity during the chronic stage of the disease, we hypothesized the role of… CONTINUE READING


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