Persisting DNA synthesis in SV40-transformed cells in the presence of cycloheximide

INHIBITION of protein synthesis decreases the rate of DNA synthesis in both prokaryotes and eukaryotes. In prokaryotes, DNA synthesis is dependent on protein synthesis only for the initiation of replication1. In the case of eukaryotes, reduction of DNA synthesis occurs rapidly after the inhibition of protein synthesis2,3, although the mechanism of the tight… (More)