Persister cells: molecular mechanisms related to antibiotic tolerance.

  title={Persister cells: molecular mechanisms related to antibiotic tolerance.},
  author={Kim Lewis},
  journal={Handbook of experimental pharmacology},
It is a given that new antibiotics are needed to combat drug-resistant pathogens. However, this is only a part of the need-we actually never had antibiotics capable of eradicating an infection. All pathogens produce a small subpopulation of dormant persister cells that are highly tolerant to killing by antibiotics. Once an antibiotic concentration drops, surviving persisters re-establish the population, causing a relapsing chronic infection. Persisters are especially significant when the… CONTINUE READING
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