Persister cells, dormancy and infectious disease

@article{Lewis2007PersisterCD,
  title={Persister cells, dormancy and infectious disease},
  author={K. Lewis},
  journal={Nature Reviews Microbiology},
  year={2007},
  volume={5},
  pages={48-56}
}
  • K. Lewis
  • Published 2007
  • Biology, Medicine
  • Nature Reviews Microbiology
Several well-recognized puzzles in microbiology have remained unsolved for decades. These include latent bacterial infections, unculturable microorganisms, persister cells and biofilm multidrug tolerance. Accumulating evidence suggests that these seemingly disparate phenomena result from the ability of bacteria to enter into a dormant (non-dividing) state. The molecular mechanisms that underlie the formation of dormant persister cells are now being unravelled and are the focus of this Review. 
1,505 Citations

Figures and Topics from this paper

Heterogeneous bacterial persisters and engineering approaches to eliminate them.
  • 159
  • PDF
Combatting Persister Cells With Substituted Indoles
  • 2
Bacterial Persister Cell Formation and Dormancy
  • 360
  • PDF
Active efflux in dormant bacterial cells - New insights into antibiotic persistence.
  • Yingying Pu, Y. Ke, F. Bai
  • Biology, Medicine
  • Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
  • 2017
  • 19
New-found fundamentals of bacterial persistence.
  • 128
  • PDF
Aminoglycoside‐Enabled Elucidation of Bacterial Persister Metabolism
  • 9
Exit from dormancy in microbial organisms
  • 147
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 100 REFERENCES
Persister cells and tolerance to antimicrobials.
  • 890
  • PDF
Persisters: a distinct physiological state of E. coli
  • 521
  • PDF
M. tuberculosis persistence, latency, and drug tolerance.
  • 452
Cannibalism by Sporulating Bacteria
  • 520
Bacterial Persistence as a Phenotypic Switch
  • 2,200
  • PDF
Candida albicans Biofilms Produce Antifungal-Tolerant Persister Cells
  • 413
  • PDF
Bacterial biofilms: from the Natural environment to infectious diseases
  • 4,881
  • PDF
The bactericidal action of penicillin: new clues to an unsolved mystery.
  • K. Bayles
  • Biology, Medicine
  • Trends in microbiology
  • 2000
  • 116
GlpD and PlsB participate in persister cell formation in Escherichia coli.
  • 173
  • PDF
...
1
2
3
4
5
...