Persistently Active, Pacemaker-Like Neurons in Neocortex

  title={Persistently Active, Pacemaker-Like Neurons in Neocortex},
  author={Morgane Le Bon-J{\'e}go and Rafael Yuste},
  journal={Frontiers in Neuroscience},
  pages={123 - 129}
The neocortex is spontaneously active, however, the origin of this self-generated, patterned activity remains unknown. To detect potential "pacemaker cells," we use calcium imaging to directly identify neurons that discharge action potentials in the absence of synaptic transmissionin slices from juvenile mouse visual cortex. We characterize 60 of these neurons electrophysiologically and morphologically, finding that they belong to two classes of cells: one class composed of pyramidal neurons… CONTINUE READING