• Corpus ID: 231925079

Persistent topology of protein space

@inproceedings{Hamilton2021PersistentTO,
title={Persistent topology of protein space},
author={W L Hamilton and Jacqueline E. Borgert and Thomas Hamelryck and J. S. Marron},
year={2021}
}
• Published 12 February 2021
• Biology
Protein fold classification is a classic problem in structural biology and bioinformatics. We approach this problem using persistent homology. In particular, we use alpha shape filtrations to compare a topological representation of the data with a different representation that makes use of knot-theoretic ideas. We use the statistical method of Angle-based Joint and Individual Variation Explained (AJIVE) to understand similarities and differences between these representations.
4 Citations

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