Persistent supersensitivity of sigma receptors develops during repeated methamphetamine treatment.

@article{Ujike1992PersistentSO,
  title={Persistent supersensitivity of sigma receptors develops during repeated methamphetamine treatment.},
  author={Hiroshi Ujike and Ken Okumura and Y Zushi and Kazufumi Akiyama and Saburo Otsuki},
  journal={European journal of pharmacology},
  year={1992},
  volume={211 3},
  pages={
          323-8
        }
}
Functional changes in sigma receptors were examined after behavioral sensitization induced by repeated methamphetamine treatment. Rats received either saline or 4 mg/kg methamphetamine for 14 days. (+)3-(3-hydroxyphenyl)-N-(1-propyl)piperidine ((+)-3-PPP), a sigma receptor agonist, was given as challenge after various periods of abstinence. (+)-3-PPP at doses greater than 6 mg/kg stimulated several forms of behavior in naive rats. (+)-3-PPP at 12 and 24 mg/kg produced more frequent rearing and… CONTINUE READING

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