Persistent protein kinase activation in the maintenance phase of long-term potentiation.

  title={Persistent protein kinase activation in the maintenance phase of long-term potentiation.},
  author={Eric Klann and Suetnee Chen and J David Sweatt},
  journal={The Journal of biological chemistry},
  volume={266 36},
Long-term potentiation (LTP) of synaptic transmission in the hippocampus is a robust form of synaptic plasticity that may contribute to mammalian memory formation. A variety of pharmacological evidence suggests that persistent kinase activation contributes to the maintenance of LTP. To determine whether persistent activation of protein kinases was associated with the maintenance phase of LTP, protein kinase activity was measured in control and LTP samples using exogenous protein kinase… CONTINUE READING


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