Persistent protease-activated receptor 4 signaling mediates thrombin-induced microglial activation.

@article{Suo2003PersistentPR,
  title={Persistent protease-activated receptor 4 signaling mediates thrombin-induced microglial activation.},
  author={Zhiming Suo and Min Wu and Bruce A Citron and Chenhua Gao and Barry W Festoff},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 33},
  pages={
          31177-83
        }
}
We have previously reported that thrombin, the ultimate serine protease in the coagulation cascades, is a proinflammatory agent that causes proliferation and activation of brain microglial cells. However, participation of its principal receptor, the protease-activated receptor 1 (PAR1) appears to be limited to promoting microglial proliferation and not induction of inflammatory mediators. In the present study, we now report that thrombin action in promoting inflammatory mediators from brain… CONTINUE READING

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