Persistent preswitch clonotypic myeloma cells correlate with decreased survival: evidence for isotype switching within the myeloma clone.

@article{Reiman2001PersistentPC,
  title={Persistent preswitch clonotypic myeloma cells correlate with decreased survival: evidence for isotype switching within the myeloma clone.},
  author={Tony J Reiman and Karen L. Seeberger and Brian J. Taylor and Agnieszka J. Szczepek and John Hanson and Michael J. Mant and Robert W Coupland and Andrew R. Belch and Linda M. Pilarski},
  journal={Blood},
  year={2001},
  volume={98 9},
  pages={2791-9}
}
Multiple myeloma (MM) is identified by unique immunoglobulin heavy chain (IgH) variable diversity joining region gene rearrangements, termed clonotypic, and an M protein termed the "clinical" isotype. Transcripts encoding clonotypic pre and postswitch IgH isotypes were identified in MM peripheral blood mononuclear cells (PBMCs), bone marrow (BM), and mobilized blood. For 29 patients, 38 BM, 17 mobilized blood, and 334 sequential PBMC samples were analyzed at diagnosis, before and after… CONTINUE READING

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