Persistent poliovirus infection of human fetal brain cells.

@article{Pavio1996PersistentPI,
  title={Persistent poliovirus infection of human fetal brain cells.},
  author={Nicole Pavio and Marie-H{\'e}l{\`e}ne Buc-Caron and Florence Colb{\`e}re-Garapin},
  journal={Journal of virology},
  year={1996},
  volume={70 9},
  pages={6395-401}
}
It has been suggested that poliovirus (PV), the causative agent of poliomyelitis, could persist in surviving patients. We have previously shown that PV can persistently infect some human cell lines in vitro, particularly neuroblastoma cell lines. We report here an ex vivo model in which PV can persistently infect primary cultures of human fetal brain cells. Two mutations involving capsid residues 142 of VP2 and 95 of VP1 were repeatedly selected during the persistent infections. These residues… CONTINUE READING
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