Persistent olfactory mucosal metaplasia and increased olfactory bulb glial fibrillary acidic protein levels following a single dose of methylsulfonyl-dichlorobenzene in mice: comparison of the 2,5- and 2, 6-dichlorinated isomers.

@article{Bahrami2000PersistentOM,
  title={Persistent olfactory mucosal metaplasia and increased olfactory bulb glial fibrillary acidic protein levels following a single dose of methylsulfonyl-dichlorobenzene in mice: comparison of the 2,5- and 2, 6-dichlorinated isomers.},
  author={Fariba Bahrami and Ulrika Bergman and Eva B. Brittebo and I. Brandt},
  journal={Toxicology and applied pharmacology},
  year={2000},
  volume={162 1},
  pages={49-59}
}
Histopathology was used to characterize long-term toxic effects in the olfactory system following a single ip dose (4-65 mg/kg) of methylsulfonyl-2,6-dichlorobenzene, (2,6-(diCl-MeSO(2)-B)), in female NMRI mice. The effects of 2,6-(diCl-MeSO(2)-B) and its 2, 5-chlorinated isomer, (2,5-(diCl-MeSO(2)-B)), on the levels of glial fibrillary acidic protein (GFAP; a biomarker for neurotoxicity) in different brain regions were examined by an enzyme-linked immunosorbent assay (ELISA). The… CONTINUE READING
7 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

Similar Papers

Loading similar papers…