Persistent neurochemical changes in neonatal piglets after hypoxia-ischemia and resuscitation with 100%, 21% or 18% oxygen.

@article{Jantzie2008PersistentNC,
  title={Persistent neurochemical changes in neonatal piglets after hypoxia-ischemia and resuscitation with 100%, 21% or 18% oxygen.},
  author={Lauren L Jantzie and P -Y Cheung and Laila Obaid and Marwan Emara and Scott T. Johnson and David L Bigam and Kathryn G. Todd},
  journal={Resuscitation},
  year={2008},
  volume={77 1},
  pages={111-20}
}
BACKGROUND Neonatal hypoxia-ischemia (HI) is a common complication of pregnancy and delivery. Conventional clinical practice is to resuscitate neonates with 100% O2, and evidence is building to suggest resuscitation with lower O2 concentrations is safer. Significant neurochemical changes are associated with HI injury and persistent changes in amino acids are related to cell death, therefore we used a swine survival model of neonatal HI-reoxygenation (HI/R) to investigate the effects of… CONTINUE READING

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