Persistent memory dysfunction is associated with bilateral hippocampal damage following experimental brain injury.

@article{Smith1994PersistentMD,
  title={Persistent memory dysfunction is associated with bilateral hippocampal damage following experimental brain injury.},
  author={Douglas H. Smith and Daniel H. Lowenstein and Thomas A. Gennarelli and T K Mcintosh},
  journal={Neuroscience letters},
  year={1994},
  volume={168 1-2},
  pages={151-4}
}
Memory dysfunction following head injury is a prominent feature in humans, yet the biological basis of this abnormality remains unknown. Following parasagittal fluid-percussion (FP) brain injury in the rat, we have previously observed profound spatial memory dysfunction relatively soon following injury (i.e. at 42 h). In the present study, we show that this memory dysfunction persists for at least 2 weeks following FP brain injury, and that it is associated with a selective bilateral loss of… CONTINUE READING

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