Persistent mechanical allodynia positively correlates with an increase in activated microglia and increased P‐p38 mitogen‐activated protein kinase activation in streptozotocin‐induced diabetic rats

@article{Cheng2014PersistentMA,
  title={Persistent mechanical allodynia positively correlates with an increase in activated microglia and increased P‐p38 mitogen‐activated protein kinase activation in streptozotocin‐induced diabetic rats},
  author={K. Cheng and H. Wang and Y.-T. Chuang and C-W Chou and H.-P. Tu and Y. Yu and L-L Chang and C-S Lai},
  journal={European Journal of Pain},
  year={2014},
  volume={18}
}
  • K. Cheng, H. Wang, +5 authors C-S Lai
  • Published 2014
  • Medicine
  • European Journal of Pain
  • In experimental early painful diabetic neuropathy, persistent hyperglycaemia induces dys‐regulated sodium channel (Navs) expression in the dorsal root ganglion (DRG) and activates microglia in the spinal dorsal horn (SDH). However, information on diabetes‐induced chronic neuropathic pain is limited. Therefore, we investigated abnormal Navs in the DRG and activated glial cells in the SDH of diabetic rats with chronic neuropathic pain. 
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