Persistent interactions between the two transmembrane clusters dictate the targeting and functional assembly of adenylyl cyclase

@article{Gu2001PersistentIB,
  title={Persistent interactions between the two transmembrane clusters dictate the targeting and functional assembly of adenylyl cyclase},
  author={Chen Gu and Alexander Sorkin and Dermot M. F. Cooper},
  journal={Current Biology},
  year={2001},
  volume={11},
  pages={185-190}
}
Adenylyl cyclases possess complex structures like those of the ATP binding cassette (ABC) transporter family, which includes the cystic fibrosis transmembrane regulator, the P-glycoprotein, and ATP-sensitive K(+) channels [1-4]. These structures comprise a cytosolic N terminus followed by two tandem six-transmembrane cassettes, each associated with a highly homologous (ATP binding) cytosolic loop [5-8]. The catalytic domains, which are located in the two large cytoplasmic loops, are highly… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 18 references

Ca 2 1 - sensitive transmembrane segments containing the N - glycosylation adenylyl cyclases

Cooper DMF, JW Karpen, KA Fagan, NE Mons
Adv Second Messenger Phosphoprotein Res • 1998

Interaction of the two cytosolic domains of mammalian adenylyl cyclase.

Proceedings of the National Academy of Sciences of the United States of America • 1996

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