Persistent integration of reprogramming factors impairs the in vitro cardiogenic potential of induced pluripotent stem cells.

Abstract

Induced pluripotent cells (iPSCs) were first generated by the laboratory of Takahashi and Yamanaka in 2006 by reprogramming somatic cells into pluripotent stem cells capable of differentiating into any cell type. In a landmark series of experiments, the Yamanaka laboratory transduced mouse fibroblasts with retroviruses coding 4 transcription factors, the so-called reprogramming factors, Oct4, Sox2, c-Myc, and Klf4. Germline transmission of murine iPS cells was reported in the following year. Shortly thereafter, human iPSCs were derived, opening new avenues for regenerative medicine with autologous patient-specific cells.

DOI: 10.1161/CIRCGENETICS.114.000825

Cite this paper

@article{Mittal2014PersistentIO, title={Persistent integration of reprogramming factors impairs the in vitro cardiogenic potential of induced pluripotent stem cells.}, author={Nikhil Mittal and Ibrahim John Domian}, journal={Circulation. Cardiovascular genetics}, year={2014}, volume={7 5}, pages={571-2} }