Persistent inhibition of the pressor and aldosterone responses to angiotensin-II by TCV-116 in normotensive subjects.

@article{Ogihara1995PersistentIO,
  title={Persistent inhibition of the pressor and aldosterone responses to angiotensin-II by TCV-116 in normotensive subjects.},
  author={Toshio Ogihara and M. S. Nagano and Jitsuo Higaki and Katsuhiko Kohara and Hiroshi Mikami},
  journal={Journal of cardiovascular pharmacology},
  year={1995},
  volume={26 3},
  pages={490-4}
}
TCV-116 is an orally active, nonpeptide antagonist of angiotensin-II type-1 receptor. The angiotensin-II antagonistic potency of TCV-116 was evaluated in normal volunteers. TCV-116 was administered at single doses of 1, 2.5, and 5 mg orally on separated days. Before, and 4, 8, and 24 h after the drug administration, angiotensin-II was infused intravenously at the rate of 2.5 to 40 ng/kg/min for 5 min each. At 2.5 mg of TCV-116, the pressor response to angiotensin-II was significantly suppressed… CONTINUE READING