Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care.

@article{Gentile2012PersistentIA,
  title={Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care.},
  author={Lori Filichia Gentile and Alex Gervacio Cuenca and Philip Alexander Efron and Darwin N. Ang and Azra Bihorac and Bruce A. McKinley and Lyle L. Moldawer and Fredrick Moore},
  journal={The journal of trauma and acute care surgery},
  year={2012},
  volume={72 6},
  pages={1491-501}
}
Surgical intensive care unit (ICU) stay of longer than 10 days is often described by the experienced intensivist as a "complicated clinical course" and is frequently attributed to persistent immune dysfunction. "Systemic inflammatory response syndrome" (SIRS) followed by "compensatory anti-inflammatory response syndrome" (CARS) is a conceptual framework to explain the immunologic trajectory that ICU patients with severe sepsis, trauma, or emergency surgery for abdominal infection often traverse… CONTINUE READING
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