Persistent infection with influenza A virus: evolution of virus mutants.

  title={Persistent infection with influenza A virus: evolution of virus mutants.},
  author={D W Frielle and Diana D Huang and Julius S. Youngner},
  volume={138 1},
A persistent infection (persistent infection I) of baby hamster kidney (BHK) cells with the WSN (H1N1) strain of influenza A virus was established using a virus stock which contained a high proportion of defective-interfering (DI) particles. Virus recovered from passage 92 (388 days) of persistent infection I was used to establish a second persistent infection (persistent infection II) in BHK cells. A number of phenotypic changes were identified in the virus isolated during the first 50… CONTINUE READING

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