Persistent infection of mice by lactate dehydrogenase-elevating virus: transient virus replication in macrophages of the spleen.


In order to assess whether the spleen is the major site of replication of lactate dehydrogenase-elevating virus (LDV) in mice during the acute phase of infection, LDV replication in the spleen was measured by electron microscopy and fluorescent antibody staining of tissue sections and northern hybridization of total spleen RNA with an LDV-specific cDNA… (More)


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