Persistent infection of human pancreatic islets by coxsackievirus B is associated with alpha interferon synthesis in beta cells.

@article{Chehadeh2000PersistentIO,
  title={Persistent infection of human pancreatic islets by coxsackievirus B is associated with alpha interferon synthesis in beta cells.},
  author={Wassim Chehadeh and Julie Kerr-conte and François Pattou and Gunnar V. Alm and Josiane Lefebvre and Pierre Wattr{\'e} and Didier Hober},
  journal={Journal of virology},
  year={2000},
  volume={74 21},
  pages={
          10153-64
        }
}
The interactions of coxsackievirus B3 (CVB3), CVB4E2 (diabetogenic), and CVB4JBV (nondiabetogenic) strains with human pancreatic islets from eight adult brain-dead donors were investigated. Persistent replication of viruses in human islets was proved by detection of viral RNA by in situ hybridization, VP1 capsid protein by immunofluorescence (IF) staining, negative-strand viral RNA by reverse transcription-PCR in extracted RNA from islets, and release of infectious particles up to 30 days after… CONTINUE READING
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