Persistent infection contributes to heterologous protective immunity against fatal ehrlichiosis.

@article{Thirumalapura2009PersistentIC,
  title={Persistent infection contributes to heterologous protective immunity against fatal ehrlichiosis.},
  author={Nagaraja R Thirumalapura and Emily C Crossley and David H Walker and Nahed Ismail},
  journal={Infection and immunity},
  year={2009},
  volume={77 12},
  pages={5682-9}
}
Human monocytotropic ehrlichiosis (HME), an emerging and often life-threatening tick-transmitted disease, is caused by the obligately intracellular bacterium Ehrlichia chaffeensis. HME is modeled in C57BL/6 mice using Ehrlichia muris, which causes persistent infection, and Ixodes ovatus Ehrlichia (IOE), which is either acutely lethal or sublethal depending on the dose and route of inoculation. A persistent primary E. muris infection, but not a sublethal IOE infection, protects mice against an… CONTINUE READING

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