Persistent induction of HIF-1α and -2α in cardiomyocytes and stromal cells of ischemic myocardium

@inproceedings{Jrgensen2004PersistentIO,
  title={Persistent induction of HIF-1α and -2α in cardiomyocytes and stromal cells of ischemic myocardium},
  author={Jan Steffen J{\"u}rgensen and C Rosenberger and Michael Sean Wiesener and Christina Warnecke and Jan H. H{\"o}rstrup and Michael Gr{\"a}fe and Sebastian Philipp and Wanja Griethe and Patrick Henry Maxwell and Ulrich Frei and Sebastian Bachmann and Roland Willenbrock and Kai-Uwe Eckardt},
  year={2004}
}
SPECIFIC AIMSIn this study we aimed to investigate the temporo-spatial pattern of induction of the oxygen-regulated α-subunits of two principal mediators of adaptation to critically low oxygen levels, hypoxia-inducible transcription factors (HIF) -1 and -2, after myocardial infarction compared with systemic hypoxia. We characterized distinct cell types expressing any HIF-α subunit after infarction. Analysis of target genes, HIF RNA changes, and expression in isolated human coronary… CONTINUE READING

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