Persistent increase in red cell size distribution width after acute diseases: A biomarker of hypoxemia?

@article{Yas2015PersistentII,
  title={Persistent increase in red cell size distribution width after acute diseases: A biomarker of hypoxemia?},
  author={Joseph W. Y{\vc}as and Jay Charles Horrow and Benjamin D. Horne},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={2015},
  volume={448},
  pages={
          107-17
        }
}
BACKGROUND A biomarker of hypoxic exposure would be useful in clinical diagnosis and prognosis. Acute hypoxia stimulates large increases in serum erythropoietin (EPO), and EPO induces formation of characteristic enlarged red blood cells (RBCs). The presence of large RBCs perturbs red cell distribution width (RDW). METHODS Using a >2M patient medical claims database, the human pathome was scanned for diseases where RDW rose 0-50days following a new diagnosis. The course of RDW after selected… CONTINUE READING
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