Persistent improvement of type 2 diabetes in the Goto-Kakizaki rat model by expansion of the beta-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4.

@article{Tourrel2002PersistentIO,
  title={Persistent improvement of type 2 diabetes in the Goto-Kakizaki rat model by expansion of the beta-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4.},
  author={C{\'e}cile Tourrel and Danielle Bailb{\'e} and Matthieu Lacorne and M J Meile and Micheline Kergoat and Bernard Portha},
  journal={Diabetes},
  year={2002},
  volume={51 5},
  pages={1443-52}
}
In the Goto-Kakizaki (GK) rat, a genetic model of type 2 diabetes, the neonatal beta-cell mass deficit is considered to be the primary defect leading to basal hyperglycemia, which is detectable for the first time 3 weeks after birth. We investigated in GK females the short- and the long-term effects of a treatment with glucagon-like peptide-1 (GLP-1) or its long-acting analog exendin-4 (Ex-4) during the first postnatal week (during the prediabetic period). GK rats were treated with daily… CONTINUE READING

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