Persistent impairment of hypothalamic KiSS-1 system after exposures to estrogenic compounds at critical periods of brain sex differentiation.

@article{Navarro2009PersistentIO,
  title={Persistent impairment of hypothalamic KiSS-1 system after exposures to estrogenic compounds at critical periods of brain sex differentiation.},
  author={Victor M Navarro and Miguel {\'A}ngel S{\'a}nchez-Garrido and Juan Manuel Castellano and Juan Roa and David Garc{\'i}a-Galiano and Rafael Pineda and Enrique Aguilar and Leonor Pinilla and Manuel Tena-Sempere},
  journal={Endocrinology},
  year={2009},
  volume={150 5},
  pages={2359-67}
}
Attainment of reproductive capacity at puberty relies on a complex series of maturational events that include sexual differentiation of the brain; a hormonally driven phenomenon that takes place at early stages of development (critical period). Alterations of sex steroid milieu during such critical period disrupt pubertal maturation and gonadotropic function later in life, through mechanisms that remain partially unknown. Kisspeptins, products of the KiSS-1 gene acting via G protein-coupled… CONTINUE READING
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