Persistent immune activation in HIV-1 infection is associated with progression to AIDS.

@article{Hazenberg2003PersistentIA,
  title={Persistent immune activation in HIV-1 infection is associated with progression to AIDS.},
  author={Mette D. Hazenberg and Sigrid A. Otto and Birgit H. B. van Benthem and Marijke T. L. Roos and Roel A. Coutinho and Joep M. A. Lange and D{\"o}rte Hamann and Maria Prins and Frank A Miedema},
  journal={AIDS},
  year={2003},
  volume={17 13},
  pages={1881-8}
}
BACKGROUND HIV-1 infection is characterized by chronic generalized CD8 and CD4 T cell hyperactivation, the biological effect of which is not understood. OBJECTIVE To study the relation between chronic immune activation and CD4 T cell depletion in HIV-1 infection. DESIGN Prospective cohort study among participants of the Amsterdam Cohort Studies on HIV-1 infection and AIDS who have a known seroconversion date (n = 102). METHODS CD4 and CD8 T cell activation marker expression was analysed… CONTINUE READING
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