Persistent hyperinsulinemic hypoglycemia and maturity-onset diabetes of the young due to heterozygous HNF4A mutations.

@article{Kapoor2008PersistentHH,
  title={Persistent hyperinsulinemic hypoglycemia and maturity-onset diabetes of the young due to heterozygous HNF4A mutations.},
  author={Ritika R. Kapoor and Jonathan M Locke and Kevin Colclough and Jerry K. H. Wales and Jennifer J Conn and Andrew T Hattersley and Sian Ellard and Khalid Hussain},
  journal={Diabetes},
  year={2008},
  volume={57 6},
  pages={1659-63}
}
OBJECTIVE Mutations in the human HNF4A gene encoding the hepatocyte nuclear factor (HNF)-4alpha are known to cause maturity-onset diabetes of the young (MODY), which is characterized by autosomal-dominant inheritance and impaired glucose-stimulated insulin secretion from pancreatic beta-cells. HNF-4alpha has a key role in regulating the multiple transcriptional factor networks in the islet. Recently, heterozygous mutations in the HNF4A gene were reported to cause transient hyperinsulinemic… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 20 references

Macrosomia and hyperinsulinaemic hypoglycae - mia in patients with heterozygous mutations in the HNF 4 A gene

  • ER Pearson, SF Boj, +6 authors AT Hattersley
  • PLoS Med
  • 2007
Highly Influential
6 Excerpts

Similar Papers

Loading similar papers…