Persistent hyperactivity following a single intracerebroventricular dose of ouabain.

  title={Persistent hyperactivity following a single intracerebroventricular dose of ouabain.},
  author={D J Ruktanonchai and Rif S. El-Mallakh and Rena Li and Robert S Levy},
  journal={Physiology & behavior},
  volume={63 3},
Intracerebroventricular (i.c.v.) administration of ouabain has been shown to alter motor activity in the rat. It has been purported that this may model the behavioral abnormalities of human manic-depressive (bipolar) illness. Since manic-depression is a recurrent condition, we elected to investigate the effects of the multiple administration of i.c.v. ouabain. Male Sprague-Dawley rats were allowed to acclimate to the animal facility for 7-10 days after which time i.c.v. cannulae were placed… CONTINUE READING

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