Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures.

@article{Li2001PersistentGI,
  title={Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures.},
  author={C Y Li and J. B. Little and Kang Quan Hu and Wei Zhang and Lei Zhang and Mark W. Dewhirst and Qian Huang},
  journal={Cancer research},
  year={2001},
  volume={61 2},
  pages={428-32}
}
A hallmark of cancer cells is their pronounced genetic instability, which has been implicated in both tumor development and negative treatment outcomes. Recently, it has been reported that ionizing radiation may induce a persistent state of hypermutability in mammalian cells that lasts for many (>30) cell divisions. In this study, we examined whether other… CONTINUE READING