Persistent gene expression changes in NAc, mPFC, and OFC associated with previous nicotine or amphetamine exposure.

@article{Mychasiuk2013PersistentGE,
  title={Persistent gene expression changes in NAc, mPFC, and OFC associated with previous nicotine or amphetamine exposure.},
  author={Richelle Mychasiuk and Arif Muhammad and Slava Ilnytskyy and Bryan Kolb},
  journal={Behavioural brain research},
  year={2013},
  volume={256},
  pages={655-61}
}
Highly addictive drugs like nicotine and amphetamine not only change an individual's behaviour in the short and long-term, they also induce persistent changes in neuronal excitability and morphology. Although research has started to examine the epigenetic changes that occur immediately after drug exposure, there has been little investigation into the persistent modifications to the epigenome that likely moderate the stable maintenance of the neurological changes. Male Long-Evans rats were… CONTINUE READING

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