Persistent gene expression after retroviral gene transfer into liver cells in vivo.

@article{Kaleko1991PersistentGE,
  title={Persistent gene expression after retroviral gene transfer into liver cells in vivo.},
  author={Michael Kaleko and J. Victor Garcia and A Dusty Miller},
  journal={Human gene therapy},
  year={1991},
  volume={2 1},
  pages={27-32}
}
The development of liver-directed gene therapy protocols depends upon the ability to transfer genes into a large number of liver cells such that the genes are expressed persistently. We used a retroviral vector to transfer the gene for neomycin phosphotransferase (neo) into mouse liver cells in vivo. Direct injection of the retrovirus preparation into mitotically active (regenerating) liver parenchyma resulted in efficient gene transfer, with neo sequences detectable in the livers of every… CONTINUE READING

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