Persistent functional deficit in multiple sclerosis and autosomal dominant cerebellar ataxia is associated with axon loss.

@article{Davie1995PersistentFD,
  title={Persistent functional deficit in multiple sclerosis and autosomal dominant cerebellar ataxia is associated with axon loss.},
  author={Charles A. Davie and Gareth J. Barker and Sharon L. Webb and Paul S. Tofts and Alan J. Thompson and Anita E. Harding and W. Ian McDonald and David H. Miller},
  journal={Brain : a journal of neurology},
  year={1995},
  volume={118 ( Pt 6)},
  pages={1583-92}
}
Proton magnetic resonance spectroscopy (MRS) and MRI were carried out in 11 patients with multiple sclerosis who had clinical evidence of severe cerebellar involvement, 11 multiple sclerosis patients (of similar age and disease duration) who had minimal or no signs of cerebellar disease, eight patients with autosomal dominant cerebellar ataxia (ADCA) and 11 healthy controls. In all subjects MRS was localized to cerebellar white matter (volumes of interest 3-6 ml). Apparent metabolite… CONTINUE READING