Persistent expression of mitogenic/transforming factors at the site of failed orthopaedic implants: the impact on immune reactivity.

Abstract

The response to wear particles from orthopaedic implants can lead to inflammation, osteolytic lesions, and aseptic loosening. To gain an insight into the development of this pathogenetic process, immunohistochemical techniques were used to identify the expression and tissue distribution of the potent cell mitogen epidermal growth factor (EGF), and the… (More)

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