Persistent expression of cytokine in the chronic stage of viral myocarditis in mice.

@article{Shioi1996PersistentEO,
  title={Persistent expression of cytokine in the chronic stage of viral myocarditis in mice.},
  author={Tetsuo Shioi and Akira Matsumori and Shigetake Sasayama},
  journal={Circulation},
  year={1996},
  volume={94 11},
  pages={2930-7}
}
BACKGROUND Dilated cardiomyopathy (DCM) is one of the most frequent causes of heart failure of unknown origin. One possible cause of DCM is considered to be a sequel to myocarditis. However, the mechanism of progression from viral myocarditis to DCM is still not clear. METHODS AND RESULTS The expression of the immunoregulatory cytokines interferon (IFN)-gamma and interleukin (IL)-2 and the proinflammatory cytokines IL-1 beta and tumor necrosis factor (TNF)-alpha in the heart tissue was… CONTINUE READING

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