Persistent expression of MNF identifies myogenic stem cells in postnatal muscles.

  title={Persistent expression of MNF identifies myogenic stem cells in postnatal muscles.},
  author={Daniel J. Garry and Quan Yang and Rhonda Bassel-Duby and R. Sanders Williams},
  journal={Developmental biology},
  volume={188 2},
Skeletal muscles contain an undifferentiated myogenic stem cell pool (satellite cells) that can be mobilized to regenerate myofibers in response to injury. We have determined that the winged helix transcription factor MNF is expressed selectively in quiescent satellite cells, which do not express known regulators of the myogenic program. Following muscle injury, MNF is present transiently in proliferating satellite cells and in centralized nuclei of regenerating myofibers, but expression… CONTINUE READING

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