Persistent endothelial abnormalities and blood–brain barrier leak in primary and secondary progressive multiple sclerosis

@article{Leech2007PersistentEA,
  title={Persistent endothelial abnormalities and blood–brain barrier leak in primary and secondary progressive multiple sclerosis},
  author={Susie Leech and John Kirk and Jonathan Plumb and Stephen McQuaid},
  journal={Neuropathology and Applied Neurobiology},
  year={2007},
  volume={33}
}
Epithelial and endothelial tight junctions are pathologically altered in infectious, inflammatory, neoplastic and other diseases. Previously, we described such abnormalities, associated with serum protein leak, in tight junctions of the blood–brain barrier endothelium, in lesional and normal‐appearing white matter (NAWM) in secondary progressive (SP) and acute multiple sclerosis (MS). This work is extended here to lesions and NAWM in primary progressive multiple sclerosis (PPMS) and to cortical… 

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...

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