Persistent depressive symptoms and cognitive function in late midlife: the Whitehall II study.

@article{SinghManoux2010PersistentDS,
  title={Persistent depressive symptoms and cognitive function in late midlife: the Whitehall II study.},
  author={Archana Singh-Manoux and Tasnime Akbaraly and Michael Marmot and Maria Melchior and Jo{\"e}l Ankri and S{\'e}verine Sabia and Jane E. Ferrie},
  journal={The Journal of clinical psychiatry},
  year={2010},
  volume={71 10},
  pages={1379-85}
}
OBJECTIVE Depression has been widely linked to poor cognition and dementia in the elderly. However, comorbidity at older ages does not allow an assessment of the role of mental health as a risk factor for cognitive outcomes. We examined the association between depressive symptoms, measured 6 times over an 18-year period, and cognitive deficits in late midlife. METHOD Of the 10,308 participants in the Whitehall II study, 4,271 men and women (aged 35-55 years at baseline) were followed up for… CONTINUE READING

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