Persistent complement activation on tumor cells in breast cancer.

  title={Persistent complement activation on tumor cells in breast cancer.},
  author={Florin Niculescu and Horea G Rus and M Retegan and Roland Vlaicu},
  journal={The American journal of pathology},
  volume={140 5},
The neoantigens of the C5b-9 complement complex, IgG, C3, C4, S-protein/vitronectin, fibronectin, and macrophages were localized on 17 samples of breast cancer and on 6 samples of benign breast tumors using polyclonal or monoclonal antibodies and the streptavidin-biotin-peroxidase technique. All the tissue samples with carcinoma in each the TNM stages presented C5b-9 deposits on the membranes of tumor cells, thin granules on cell remnants, and diffuse deposits in the necrotic areas. When… CONTINUE READING