Persistent changes in peripheral and spinal nociceptive processing after early tissue injury

@article{Walker2016PersistentCI,
  title={Persistent changes in peripheral and spinal nociceptive processing after early tissue injury},
  author={S. Walker and S. Beggs and M. Baccei},
  journal={Experimental Neurology},
  year={2016},
  volume={275},
  pages={253-260}
}
It has become clear that tissue damage during a critical period of early life can result in long-term changes in pain sensitivity, but the underlying mechanisms remain to be fully elucidated. Here we review the clinical and preclinical evidence for persistent alterations in nociceptive processing following neonatal tissue injury, which collectively point to the existence of both a widespread hypoalgesia at baseline as well as an exacerbated degree of hyperalgesia following a subsequent insult… Expand
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