Persistent changes in gene expression induced by estrogen and progesterone in the rat mammary gland.

@article{Ginger2001PersistentCI,
  title={Persistent changes in gene expression induced by estrogen and progesterone in the rat mammary gland.},
  author={Melanie R Ginger and Maria Gonzalez-Rimbau and Jason Gay and Jeffrey M. Rosen},
  journal={Molecular endocrinology},
  year={2001},
  volume={15 11},
  pages={
          1993-2009
        }
}
Epidemiological studies have consistently shown that an early full-term pregnancy is protective against breast cancer. We hypothesize that the hormonal milieu that is present during pregnancy results in persistent changes in the pattern of gene expression in the mammary gland, leading to permanent changes in cell fate that determine the subsequent proliferative response of the gland. To investigate this hypothesis, we have used suppression subtractive hybridization to identify genes that are… CONTINUE READING

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