Persistent centrilobular necroses in hepatic allografts.

  title={Persistent centrilobular necroses in hepatic allografts.},
  author={Jurgen Ludwig and John B. Gross and James D. Perkins and S. Breanndan Moore},
  journal={Human pathology},
  volume={21 6},
A biopsy study of 60 allografts from 53 patients after orthotopic liver transplantation (OLT) revealed prominent centrilobular necrosis (CN) in 18% of the grafts that were suitable for analysis. The lesions often had a "punched-out" appearance, sometimes with unusual features such as giant cell formation. Persistent CN developed 4 weeks to 6 months after OLT, and persisted in two cases for 2 years and longer. In some instances, CN disappeared or healed by scarring. We found no association… CONTINUE READING