Persistent behavioral alterations in rats neonatally exposed to low doses of the organophosphate pesticide, parathion.

@article{Timofeeva2008PersistentBA,
  title={Persistent behavioral alterations in rats neonatally exposed to low doses of the organophosphate pesticide, parathion.},
  author={Olga Arnoldovna Timofeeva and David B. Sanders and Kristen Seemann and Liwei Yang and Daniel J. Hermanson and Sam Regenbogen and Samantha Agoos and Anita Kallepalli and Anit Rastogi and David Braddy and Corinne N Wells and Charles Perraut and Frederic J. Seidler and Theodore A. Slotkin and Edward D. Levin},
  journal={Brain research bulletin},
  year={2008},
  volume={77 6},
  pages={404-11}
}
Although developmental exposures of rats to low levels of the organophosphate pesticides (OPs), chlorpyrifos (CPF) or diazinon (DZN), both cause persistent neurobehavioral effects, there are important differences in their neurotoxicity. The current study extended investigation to parathion (PTN), an OP that has higher systemic toxicity than either CPF or DZN. We gave PTN on postnatal days (PND) 1-4 at doses spanning the threshold for systemic toxicity (0, 0.1 or 0.2 mg/kg/day, s.c.) and… CONTINUE READING

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