Persistent antihypertensive effect of aliskiren is accompanied by reduced proteinuria and normalization of glomerular area in Ren-2 transgenic rats.

@article{Rakuan2010PersistentAE,
  title={Persistent antihypertensive effect of aliskiren is accompanied by reduced proteinuria and normalization of glomerular area in Ren-2 transgenic rats.},
  author={Dan Raku{\vs}an and Petr Kujal and Herbert J. Kramer and Zuzana Huskov{\'a} and Zdeňka Vaňourkov{\'a} and Zdeňka Vernerov{\'a} and Iveta Mr{\'a}zov{\'a} and Monika Thumov{\'a} and Luděk {\vC}ervenka and Ivana Vaně{\vc}kov{\'a}},
  journal={American journal of physiology. Renal physiology},
  year={2010},
  volume={299 4},
  pages={F758-66}
}
The effects of the human renin inhibitor aliskiren on blood pressure (BP), end-organ damage, proteinuria, and tissue and plasma angiotensin (ANG) II levels in young and adult heterozygous Ren-2 transgenic rats (TGR) were evaluated and compared with the effect of the ANG type 1 (AT(1)) receptor blocker losartan during treatment and after 12 days after the withdrawal of drug treatments. BP was monitored by telemetry from the age of 32 days on (young rats) and at 100 days (adult rats). Aliskiren… CONTINUE READING