Persistent and Compartmentalised Disruption of Dendritic Cell Subpopulations in the Lung following Influenza A Virus Infection

  title={Persistent and Compartmentalised Disruption of Dendritic Cell Subpopulations in the Lung following Influenza A Virus Infection},
  author={Deborah H Strickland and Vanessa S. Fear and Seth Shenton and M E Wikstrom and Graeme R. Zosky and Alexander N. Larcombe and Patrick G. Holt and Cassandra M. Berry and Christophe von Garnier and Philip A. Stumbles},
  journal={PLoS ONE},
Immunological homeostasis in the respiratory tract is thought to require balanced interactions between networks of dendritic cell (DC) subsets in lung microenvironments in order to regulate tolerance or immunity to inhaled antigens and pathogens. Influenza A virus (IAV) poses a serious threat of long-term disruption to this balance through its potent pro-inflammatory activities. In this study, we have used a BALB/c mouse model of A/PR8/34 H1N1 Influenza Type A Virus infection to examine the… 

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