Persistent and Compartmentalised Disruption of Dendritic Cell Subpopulations in the Lung following Influenza A Virus Infection

@article{Strickland2014PersistentAC,
  title={Persistent and Compartmentalised Disruption of Dendritic Cell Subpopulations in the Lung following Influenza A Virus Infection},
  author={Deborah H Strickland and Vanessa S. Fear and Seth Shenton and M E Wikstrom and Graeme R. Zosky and Alexander N. Larcombe and Patrick G. Holt and Cassandra M. Berry and Christophe von Garnier and Philip A. Stumbles},
  journal={PLoS ONE},
  year={2014},
  volume={9}
}
Immunological homeostasis in the respiratory tract is thought to require balanced interactions between networks of dendritic cell (DC) subsets in lung microenvironments in order to regulate tolerance or immunity to inhaled antigens and pathogens. Influenza A virus (IAV) poses a serious threat of long-term disruption to this balance through its potent pro-inflammatory activities. In this study, we have used a BALB/c mouse model of A/PR8/34 H1N1 Influenza Type A Virus infection to examine the… 
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References

SHOWING 1-10 OF 60 REFERENCES
Respiratory Dendritic Cell Subsets Differ in Their Capacity to Support the Induction of Virus-Specific Cytotoxic CD8+ T Cell Responses
TLDR
CD103+ and CD11bhi RDC are identified as critical regulators of the adaptive immune response to respiratory tract infection and potential targets in the design of mucosal vaccines.
Sustained increases in numbers of pulmonary dendritic cells after respiratory syncytial virus infection.
Unique Type I Interferon Responses Determine the Functional Fate of Migratory Lung Dendritic Cells during Influenza Virus Infection
TLDR
The “interferon-resistant” CD103+ DCs may have evolved to ensure the presentation of viral antigens to T cells in I-IFN rich environments and this trait may be exploitable by viral pathogens as a mechanism for systemic dissemination.
Dendritic Cells Are Recruited into the Airway Epithelium during the Inflammatory Response to a Broad Spectrum of Stimuli
TLDR
It is demonstrated that recruitment of a wave of DC into the respiratory tract mucosa is a universal feature of the acute cellular response to local challenge with bacterial, viral, and soluble protein antigens, and that freshly isolated respiratory mucosal DC respond in vitro to a variety of CC chemokines as well as complementary cleavage products.
A critical function for CD200 in lung immune homeostasis and the severity of influenza infection
TLDR
It is demonstrated here that airway macrophages had higher expression of the negative regulator CD200 receptor (CD200R) than did their systemic counterparts and were restrained by CD200 expressed on airway epithelium, which limits inflammatory amplitude and duration during pulmonary influenza infection.
Inflammatory infiltration of the upper airway epithelium during Sendai virus infection: involvement of epithelial dendritic cells
TLDR
It is found that Sendai virus infection was restricted to only the lumenal layer of epithelial cells and that virus nucleoprotein was present from days 2 to 5 postinfection and that when cultured in the presence of gamma interferon, class II antigen was induced on epithelium.
Accelerated migration of respiratory dendritic cells to the regional lymph nodes is limited to the early phase of pulmonary infection.
Regulation of Dendritic Cell Recruitment into Resting and Inflamed Airway Epithelium: Use of Alternative Chemokine Receptors as a Function of Inducing Stimulus1
TLDR
Comparable levels of DC recruitment were observed during airway mucosal Sendai virus infection and after aerosol challenge of sensitized animals with the soluble recall Ag OVA, indicating the use of alternative chemokine receptors/ligands for DC recruitment, or possibly attraction of different DC subsets, depending on the nature of the eliciting stimulus.
Influenza Virus–induced Dendritic Cell Maturation Is Associated with the Induction of Strong T Cell Immunity to a Coadministered, Normally Nonimmunogenic Protein
TLDR
Respiratory infection can induce DC maturation and simultaneously B and T cell immunity to an innocuous antigen inhaled concurrently.
Mobilization of plasmacytoid and myeloid dendritic cells to mucosal sites in children with respiratory syncytial virus and other viral respiratory infections.
TLDR
Infection with RSV and other respiratory viruses mobilizes DCs to the site of viral entry, and Immunochemistry analysis of respiratory samples has demonstrated the presence of the RSV fusion protein within HLA-DR-positive cells.
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